Stephanie Portet

(Mathematics, University of Manitoba)

Dynamics of the intermediate filament assembly

Date Tuesday, March 18, 2008

The cytoskeleton is a complex arrangement of structural proteins organized in networks: microfilaments, intermediate filaments and microtubules. Each network has specific properties and organization as well as particular roles in the cell. The organization of a cytoskeletal network is the main determinant of its cellular function. Here, the organization of the intermediate filament network is studied. Models of the assembly of an intermediate filament, and the distribution of the intermediate filament material in the cell are developed. Different hypotheses are tested by mathematical and computational analyses.